The Thymus Gland

    The thymus is a specialized organ of the immune system. The thymus “educates” T-lymphocytes (T cells), which are critical cells of the adaptive immune system.

    Each T cell attacks a foreign substance which it identifies with its receptor. T cells have receptors which are generated by randomly shuffling gene segments. Each T cell attacks a different antigen. T cells that attack the body’s own proteins are eliminated in the thymus. Thymic epithelial cells express major proteins from elsewhere in the body, and T cells that respond to those proteins are eliminated through programmed cell death (apoptosis).

    The thymus is composed of two identical lobes and is located anatomically in the anterior superior mediastinum, in front of the heart and behind the sternum.

    Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T-cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin (derived from bone marrow resident hematopoietic stem cells). Developing T-cells are referred to as thymocytes and are of hematopoietic origin. Stromal cells include thymic cortical epithelial cells, thymic medullary epithelial cells, and dendritic cells.

    The thymus provides an inductive environment for development of T-lymphocytes from hematopoietic progenitor cells. In addition, thymic stromal cells allow for the selection of a functional and self-tolerant T-cell repertoire. Therefore, one of the most important roles of the thymus is the induction of central tolerance.

    The thymus is largest and most active during the neonatal and pre-adolescent periods. By the early teens, the thymus begins to atrophy and thymic stroma is replaced by adipose (fat) tissue. Nevertheless, residual T lymphopoiesis continues throughout adult life.

From the following article: Developing a new paradigm for thymus organogenesis ~ C. Clare Blackburn & Nancy R. Manley ~ Nature Reviews Immunology 4, 278-289 (April 2004) ~ doi:10.1038/nri1331

And this is some esoteric shit right here

We have been thinking about vaccination of our baby, and so far have decided not to. There has been an outbreak of whooping cough this season in Tamaki Makau Rau, and there have been widespread recommendations and some fearmongering about vaccination. We chose to keep our baby unvaccinated and try to support her immune system as well as possible, by keeping her away from enclosed public places as much as possible, by wearing her on our bodies, by breastfeeding as much as possible, and by surrounding her with as much love as possible. Even though her start to life wasn’t super easy, she is really strong and alive. The thymus seems to be a key part of the immune system to support, as it is a teacher.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s